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A practical approach to the asymmetric synthesis of the ring A substructure of genkwadane A, a daphnane diterpenoid, was developed. This synthesis features the Mukaiyama aldol reaction to introduce the quaternary stereogenic center at C4 and VO(acac)2‐catalyzed Jackson‐Ellman‐Bolm sulfoxidation to deliver the corresponding sulfoxide. The Dieckmann‐type condensation was efficiently promoted by KHMDS...
The back cover picture shows Genkwadane A was isolated from the flower buds of Daphne genkwa which shows bioactivity against HeLa, HepG2, HT‐1080, MCF‐7, A549, U‐937, K562 and HL60 cell lines. It is the first time that a daphnane diterpenoid bearing a 1,10‐double bond was isolated. In this paper, B. Liu and co‐workers report asymmetric synthesis of the ring A substructure of genkwadane A in 10 steps...
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