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Hepatocyte growth factor receptor is identified as a heterodimeric tyrosine kinase encoded by the c-met gene. This study was designed to determine how the c-met/hepatocyte growth factor receptor participates in the intracellular events involved in rat liver regeneration induced by administration of carbon tetrachloride.Expressin of the rat c-met mRNA increased, peaking 24 h after carbon tetrachloride...
During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase C α subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase C α subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing...
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