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•The endogenous reactivation of HHV-6/7 may result in Pityriasis rosea (PR).•The blood viral load distinguishes between latent and clinically manifest disease.•We compared HHV-7/6 DNA load in saliva and blood samples of PR patients and controls.•Salivary PCR assay is inadequate to detect and follow-up HHV-7 reactivation in PR.•Only the plasma viral DNA load remains the direct marker of the viral replication.
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