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The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1α and tumor necrosis factor (TNF) α, and the concentrations of activin A, follistatin, and MMP-3 secreted into the culture media were measured by enzyme-linked...
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