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In article number 1701527, Sangeeta N. Bhatia and co‐workers engineer an antibacterial by fusing two peptide domains to target and kill bacteria and then encapsulate them in a biodegradable porous silicon nanoparticle. These nanomaterials kill bacteria and improve animal survival after treatment of a lung‐infection model. This approach represents a new strategy for the development of antibacterials...
There is an urgent need for new materials to treat bacterial infections. In order to improve antibacterial delivery, an anti‐infective nanomaterial is developed that utilizes two strategies for localization: i) a biodegradable nanoparticle carrier to localize therapeutics within the tissue, and ii) a novel tandem peptide cargo to localize payload to bacterial membranes. First, a library of antibacterial...
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