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Bi‐clonality is a rare phenomenon seen in approximately 5% of chronic B‐cell lymphoproliferative disorders. Both true bi‐clonality and somatic hypermutation resulting in intraclonal evolution have been described. We present the case of a 37‐year‐old female who developed extranodal marginal zone B‐cell lymphoma with immunohistochemical studies showing monotypic immunostaining of plasma cells for immunoglobulin...
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