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Background
Cisplatin‐based chemoradiotherapy is standard of care for locally advanced squamous cell carcinoma of the head and neck. This systemic review compared efficacy and safety of weekly vs triweekly cisplatin in locally advanced squamous cell carcinoma of the head and neck.
Methods
Among 1500 prospective studies published from 1970 to 2015, 39 (18 weekly, 21 triweekly) including 3668 patients...
BACKGROUND
Monoclonal antibodies against programmed cell death protein 1 (PD‐1) and programmed death ligand 1 (PD‐L1) are effective therapies in patients with non‐small cell lung cancer (NSCLC). Herein, the authors performed a systematic review investigating differences in the toxicities of PD‐1 and PD‐L1 inhibitors.
METHODS
An electronic literature search was performed of public databases (MEDLINE,...
BACKGROUND
Human epidermal growth factor receptor 2 (HER2) mutations have been reported in lung adenocarcinomas. Herein, the authors describe the prevalence, clinical features, and outcomes associated with HER2 mutations in 1007 patients in the Lung Cancer Mutation Consortium (LCMC).
METHODS
Patients with advanced‐stage lung adenocarcinomas were enrolled to the LCMC. Tumor specimens were assessed...
BACKGROUNDThe discovery of oncogenic drivers has ushered in a new era for lung cancer, but the role of these mutations in different racial/ethnic minorities has been understudied. The Lung Cancer Mutation Consortium 1 (LCMC1) database was investigated to evaluate the frequency and impact of oncogenic drivers in lung adenocarcinomas in the racial/ethnic minority patient population.
METHODSPatients...
BACKGROUNDThe last 3 decades have witnessed limited therapeutic advances in small cell lung cancer (SCLC) management. This study evaluated real‐world trends in the use of systemic therapies and the impact on patient outcomes in the United States.
METHODSThe Surveillance, Epidemiology, and End Results–Medicare database was used to find patients diagnosed with SCLC between 1985 and 2005. The 1985‐1990...
BACKGROUNDAlthough heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head and neck cancer, their prognostic value remains unclear. The authors explored the prognostic significance of heregulin/HER3 expression in patients with oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well as p16...
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