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Phosphorus MRSI (31P–MRSI) using a spiral‐trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle.
The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunteers, who performed a plantar flexion exercise inside a whole‐body 7 T MR scanner using...
PurposeSimultaneous acquisition of spatially resolved 31P‐MRI data for evaluation of muscle specific energy metabolism, i.e., PCr and pH kinetics.
MethodsA three‐dimensional (3D) gradient‐echo sequence for multiple frequency‐selective excitations of the PCr and Pi signals in an interleaved sampling scheme was developed and tested at 7 Tesla (T). The pH values were derived from the chemical shift‐induced...
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