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Phleboviruses are a group of emerging viruses with a wide spectrum of virulence: For example, Rift Valley Fever virus (RVFV) is highly pathogenic, whereas Sandfly fever Sicilian virus (SFSV) causes intermediate pathogenicity.The major virulence factor is the non-structural protein NSs, a suppressor of the type I interferon (IFN) system. While the NSs protein of highly pathogenic RVFV inhibits global...
The Pyrin and HIN200 domain-containing (PYHIN) protein family consists of AIM2, IFI16, MNDA, PYHIN1 and POP3 in humans and at least 13 proteins in mouse. Mouse AIM2 and p204 have been previously described to be intracellular dsDNA sensors leading to caspase-1 activation and STING-dependent IFN-β induction respectively. However the function of most mouse PYHIN proteins remains unknown. Here we characterized...
Tick-borne encephalitis virus (TBEV; family Flaviviridae), a positive sense, single-stranded RNA virus, is the medical most important arbovirus in Europe and Russia. TBEV has a significant impact on public health as it causes ∼10,000 annual cases of encephalitis and meningitis, and no antiviral treatment is available. We are investigating TBEVs interactions with the interferon (IFN) system. Therefore,...
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