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Pyrazolones represent an important structural motif in active pharmaceutical ingredients. Their asymmetric synthesis is thus widely studied. Still, a generally highly enantio‐ and diastereoselective 1,4‐addition to nitroolefins providing products with adjacent stereocenters is elusive. In this article, a new polyfunctional CuII‐1,2,3‐triazolium‐aryloxide catalyst is presented which enables this reaction...
Pyrazolone repräsentieren ein strukturell wichtiges Motiv in vielen Wirkstoffen. Ihre asymmetrische Synthese ist daher gut untersucht. Trotzdem ist eine enantio‐ sowie diastereoselektive 1,4‐Addition an Nitroolefine, die Produkte mit benachbarten Stereozentren bildet, kaum bekannt. In diesem Artikel wird ein neuartiger, polyfunktioneller CuII‐1,2,3‐Triazolium‐Aryloxid‐Katalysator vorgestellt, der...