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Surface roughness of titanium‐based implants may enhance osteogenic differentiation of cells in vitro and bone‐to‐implant contact in vivo. Nevertheless, how surface roughness regulates the signaling pathway of osteoblasts is little understood. The study intended to investigate specifically the roles of extracellular signal‐regulated kinase 1/2 (ERK1/2) pathway in regulating osteogenic differentiation...
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