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Within the phospholipase A 2 (PLA 2 ) superfamily, secreted PLA 2 (sPLA 2 ) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His-Asp catalytic dyad. Individual sPLA 2 s exhibit unique tissue and cellular localizations and specific enzymatic properties, suggesting distinct biological roles. Individual sPLA 2 ...
Mammalian genomes encode genes for more than 30 phospholipase A 2 s (PLA 2 s) or related enzymes, which are subdivided into several classes including low-molecular-weight secreted PLA 2 s (sPLA 2 s), Ca 2+ -dependent cytosolic PLA 2 s (cPLA 2 s), Ca 2+ -independent PLA 2 s (iPLA 2 s), platelet-activating factor acetylhydrolases...
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