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Endothelin1 (ET1) is a potent vasoconstrictor that is also known to be a neuropeptide that is involved in neural circuits. We examined the role of ET1 that has been implicated in the anxiogenic process. We found that infusing ET1 into the IL cortex increased anxiety-like behaviors. The ETA receptor (ETAR) antagonist (BQ123) but not the ETB receptor (ETBR) antagonist (BQ788) alleviated ET1-induced...
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