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Hydroxysafflower yellow A (HSYA) protects against acute kidney injury through TLR4/NF‐κB pathway. However, the effect and potential mechanism of HSYA in ulcerative colitis (UC) have been rarely reported, which is thus investigated in this research. An in vivo UC model was established by oral administration of 5% dextran sulfate sodium (DSS) in Sprague–Dawley rats. After HSYA treatment, the daily body...