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Using, in combination, phenotyping by isoelectric focusing and immunoblotting and genotyping by restriction fragment length analysis, we identified two individuals with a new apolipoprotein E2 variant, apolipoproten E2-Frankfurt (Arg 136 -> Cys). In a healthy 42 year old woman with normal plasma lipoprotein concentrations (cholesterol (C) 1.98 g/l, triglycerides (TG) 1.30 g/l;...
Hemostatic factors play an important role in the development of cardiovascular disease. Deficiency of protein C, a key component of the anticoagulant system, is an established risk factor of thromboembolic disease. Protein C exerts its anticoagulant function by cleaving proteolytically the active forms of the coagulation factors V and VIII. An impaired anticoagulant response to activated protein...
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