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Our previous data showed that neprilysin (NEP), a zinc metalloendopeptidase, which can degrade amyloid-β peptide (Aβ) whose central nerve system accumulation is the primary cause of Alzheimer’s disease (AD), responds to estrogen in the brain. Recently, it has been shown that the transcription of the neprilysin gene can be up regulated by progesterone, androgens, and glucocorticoids through two androgen...
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