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Alzheimer's disease (AD) is characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms. It is the most common cause of dementia. It is recognized that the production and maintenance of myelin is essential for normal brain function. Aging-related breakdown of myelin negatively impacts the cognitive performances with the neurofibrilary...
MR elastography is a new technique using conventional MRI system to assess the elastic properties of tissues. When using pneumatic driver, usually one driver was put at one place of tissue. But the shear wave generated by one pneumatic driver cannot illuminate the large area due to the attenuation. So we use two pneumatic drivers driven synchronously to generate interference shear wave in our experiments...
Magnetic Resonance Elastography (MRE) is a phase-contrast technique using conventional Magnetic Resonance Imaging system to visualize propagating shear waves and study the stiffness of tissues. Usually, shear vibrations are applied to the surface of tissues by means of mechanical driver at one point. But in femoral artery study, the shear wave generated by the single driver on the surface of thigh...
Magnetic Resonance Elastography (MRE) is a phase contrast imaging technique to quantitatively measure the elasticity of tissues. Typically, an oscillating driver is placed on the surface to generate the shear waves. The depth penetration of the wave is limited by attenuation and the biopsy procedure has to be done separately. In this study, we use a biopsy needle as the driver to detect the 15% porcine...
Cyclooxygenase (COX) is crucial in inflammation and plays important role in cerebral ischemia. Antiinflammatory effects of melatonin have been verified in previous studies. In this study, cerebral blood flow (CBF) was monitored during operation, infarct volume (IFV) was determined with 5-triphenyltetrazolium chloride (TTC) staining and MR image, and neurological functions were evaluated with turn...
Magnetic resonance elastography (MRE) is a phase contrast-based method for observing shear wave propagation in a material to determine its stiffness. The objective of this study was to determine whether shear waves suitable for MRE could be induced using a moving acupuncture needle. Tissue-simulating bovine gel phantom and a 0.4 mm diameter acupuncture needle were used in the experiment. The results...
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