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One of the most important link in improves diagnostic accuracy and disease cure rate is accurate classification of disease. The current gene chip's development and widely applications making the diagnosis based on tumor gene expression profiling expected to be on a fast and effective clinical diagnostic method. But the sample of gene is small and the expression data is multi-variable. In this article,...
Discussed are enabling biophotonic technologies that provide in-vivo like information earlier in drug discovery. The development of resonant waveguide sensor based high-throughput screening platform and utilization for studying signaling in cells will be described.
Posttranslational modifications mediate important regulatory functions in biology. The acetylation of the p53 transcription factor, for example, promotes transcriptional activation of target genes including p21. Here we show that the acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains. UV irradiation of cells diacetylates...
Microfluidic droplet systems have shown great promise in high throughput chemical assays to minimize chemical consumption and increase process efficiency. We report a droplet system that forms nanovolume drops under static conditions. The programmability of drop sizes is determined by geometric configurations and surface tension, and not particularly sensitive to flow rates. The geometry of the device...
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