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A series of 4‐hydroxycoumarin‐derived compounds 8a‐p containing N‐benzyl‐1,2,3‐triazole motif were designed as AChE inhibitors. The title compounds were obtained conveniently using multicomponent click reaction. The in vitro anticholinesterase evaluation of synthesized compounds against AChE and BuChE showed that some of them are potent and selective inhibitors of AChE. Among them, 2‐chlorobenzyl...
A series of triazole‐containing carbazole derivatives were designed as new anti‐acetylcholinesterase (AChE) agents. The target compounds 6a–q were simply prepared via a one‐pot three‐component click reaction of N‐propargyl‐9H‐carbazole, sodium azide, and an appropriate benzyl halide. The in vitro anti‐cholinesterase assay showed that the unsubstituted benzyl derivative 6p along with the 2‐F, 2‐Me,...
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