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The human β-secretase enzyme, BACE1, mediates a critical step in the production of Aβ 40 and Aβ 42 peptides which are responsible for the severe neuronal cell death and insoluble amyloid plaques of Alzheimer's disease (AD). Several lines of evidence suggest that potent BACE1 inhibitors represent an attractive Aβ-lowering strategy for AD. We designed a simple homogeneous time-resolved...
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