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(+)-α-[ 11 C]Dihydrotetrabenazine ((+)-[ 11 C]DTBZ), a radioligand for the vesicular monoamine transporter type 2 (VMAT2), has been previously proposed as an in vivo marker of beta-cell degeneration in the pancreas. The stereospecificity of uptake of [ 11 C]DTBZ into rat pancreas was examined here using radiolabeled forms of the (+)- and (−)-isomers. Pancreas localization of...
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