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Aims
We investigated whether major gastrectomy influences the plasma exposure of regorafenib and treatment outcome.
Methods
Efficacy and pharmacokinetic data from 133 gastrointestinal stromal tumour patients included in a phase III trial were analysed. Patients were subdivided into 2 groups according to the extent of the gastrectomy (no/nonsignificant gastrectomy and major gastrectomy). Progression‐free...
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