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Three series of flavonoid derivatives were designed and synthesized. All synthesized compounds were evaluated for cytotoxic activities against five human cancer cell lines, including K562, PC-3, MCF-7, A549, and HO8910. Among the compounds tested, compound 9d exhibited the most potent cytotoxic activity with IC50 values of 2.76–6.98μM. Further comparative molecular field analysis was performed to...
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