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d-methylphenidate is an enantiomer of d,l-methylphenidate and was developed as an improved treatment for attention deficit hyperactivity disorder in children. The current study was performed to determine and compare the toxicity of 2-50 mg/kg per day d-MPH and 100 mg/kg per day d,l-MPH for 90 days in rats with the top d-MPH dose being equimolar to 100 mg/kg d,l-MPH. The top d-MPH and d,l-MPH doses...
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