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Lecithin:cholesterol acyltransferase (LCAT) is the enzyme responsible for generation of the majority of the cholesteryl esters (CE) in human plasma. Although most plasma cholesterol esterification occurs on high-density lipoprotein (HDL), via α-LCAT activity, esterification also occurs on low-density lipoprotein (LDL) via the β-activity of the enzyme. Computer threading techniques have provided a...
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