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Drug Screening
In article number 2207194, Mengsu Yang and co‐workers design a high throughput microfluidic chip that could achieve multi‐function drug screening against collective migration of cancer cells under confined environment. Using this device, three new compounds that could significantly inhibit confined migration of cancer cells are found: MA‐5, SB‐705498 and diphenyleneiodonium chloride...
Cancer metastasis is the major cause of cancer‐related death. Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors, creating confined spaces for tumor cell migration and metastasis. Confined migration is involved in all metastasis steps. However, confined and unconfined migration inhibitors are different and drugs available to inhibit confined migration...
Infection classification is the key for choosing the proper treatment plans. Early determination of the causative agents is critical for disease control. Host responses analysis can detect variform and sensitive host inflammatory responses to ascertain the presence and type of the infection. However, traditional host‐derived inflammatory indicators are insufficient for clinical infection classification...
Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics, temozolomide is considered as the first‐line drug for GBM therapy, but the treatment outcome is not satisfactory. Notably, regorafenib, an oral multi‐kinase inhibitor, has been reported to exert a markedly superior effect on GBM suppression...
Chemo‐phototherapy has emerged as a promising approach to complement traditional cancer treatment and enhance therapeutic effects. However, it still faces the challenges of drug efflux transporter‐mediated chemoresistance and heat shock proteins (HSPs)‐mediated phototherapy tolerance, which both depend on an excessive supply of adenosine triphosphate. Therefore, manipulating energy metabolism to impair...
In article number 1800288, Ye Zhou, Su‐Ting Han, Vellaisamy A. L. Roy, and co‐workers develop a biological spiking synaptic device with important synaptic behaviors constructed from solution processed bimetal core‐shell nanoparticle based composites. This work demonstrates that the polymer–metal nanoparticle composites based artificial synaptic devices have great potential for the realization of a...
Inspired by the highly parallel processing power and low energy consumption of the biological nervous system, the development of a neuromorphic computing paradigm to mimic brain‐like behaviors with electronic components based artificial synapses may play key roles to eliminate the von Neumann bottleneck. Random resistive access memory (RRAM) is suitable for artificial synapse due to its tunable bidirectional...
Following the trend of miniaturization as per Moore's law, and facing the strong demand of next‐generation electronic devices that should be highly portable, wearable, transplantable, and lightweight, growing endeavors have been made to develop novel flexible data storage devices possessing nonvolatile ability, high‐density storage, high‐switching speed, and reliable endurance properties. Nonvolatile...
In article number 1703126, Su‐Ting Han, Vellaisamy A. L. Roy, Ye Zhou, and co‐workers summarize the recent developments in flexible organic non‐volatile data storage devices from transistor based memory to resistive memory. Growing endeavors have been made to achieve high‐density storage, high‐switching speed and reliable endurance properties. The fantastic nonvolatile memory applications will set...
DNA micro‐ and nanogels—small‐sized hydrogels made of a crosslinked DNA backbone—constitute new promising materials, but their functions have mainly been limited to those brought by DNA. Here a new way is described to prepare sub‐micrometer‐sized DNA gels of controllable crosslinking density that are able to embed novel functions, such as an enzymatic activity. It consists of using proteins, instead...
V. A. L. Roy and co‐workers present a novel hybrid architecture to achieve programmable transistor nodes that are analogous to flash memory. On page 390, they incorporate a resistive switching random access memory as a switch gate for a transistor on a flexible substrate. The controlled, well‐defined memory window, long retention time, and fast access speed of this novel hybrid device may open up...
Here, a single‐device demonstration of novel hybrid architecture is reported to achieve programmable transistor nodes which have analogies to flash memory by incorporating a resistive switching random access memory (RRAM) device as a resistive switch gate for field effect transistor (FET) on a flexible substrate. A high performance flexible RRAM with a three‐layered structure is fabricated by utilizing...
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