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Sirtuin‐3 (SIRT3) regulates mitochondrial quality and is involved in the anti‐ageing and pro‐longevity actions of caloric restriction (CR). Here, we show that CR upregulates the mature form of SIRT3 and mitochondrial intermediate peptidase (MIPEP), a mitochondrial signal peptidase (MtSPase), in white adipose tissue. We also demonstrate that upregulation of mature SIRT3 is dependent on MIPEP in 3T3‐L1...
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