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CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through the Nrf2–Keap1 pathway, an important mechanism for the induction of cytoprotective genes in response to oxidative stress. Upon oxidative or electrophilic insult, the transcription factor Nrf2 translocates to the nucleus, heterodimerizes with small Maf proteins, and binds to antioxidant response elements (AREs)...
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