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(±)‐Involucrasin C (1), a pair of new 2,3‐dihydro‐1H‐indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures were established by the basis of comprehensive spectroscopic data analysis and X‐ray crystallographic diffraction. Both 1 and 2 significantly inhibited the secretion of pro‐inflammatory cytokines IL‐6, TNF‐α, and IL‐1β, suggesting...