The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
By means of limited proteolysis assay, three‐dimensional NMR, X‐ray crystallography and alanine mutations, a dynamic region at the Q221R222N223 motif in the Bcl‐2 homology 3 (BH3) domain of Mcl‐1 has been identified as a conformational switch which controls Mcl‐1 ubiquitination. NoxaBH3 binding biases the QRN motif toward a helical conformation, thus leading to an enhanced in vitro ubiquitination...
Eine verstärkte Bindung von Mcl‐1 mit Mule könnte dessen Ubiquitinierung katalysieren und einen apoptotischen Signalweg in Krebszellen verstärken. In ihrer Zuschrift auf S. 14462 ff. identifizieren Z. Zhang und Mitarbeiter eine Verbindung, die diese beiden Proteine aneinander bindet, indem sie ein nichthelikales QRN‐Motiv auf Mcl‐1 in eine helikale Konformation überführt.
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.