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Discovering similar diseases is very helpful for revealing the pathogenesis of diseases and making direction in drug use. And related diseases are often triggered by disease-related genes. Therefore, function interaction networks structured by disease-related genes are suitable for measurement of disease similarity, and some methods have utilized the advantage of function interaction of disease-related...
It is critical yet remains to be challenging to make right disease diagnosis based on complex clinical characteristic and heterogeneous genetic background. Recently, Human Phenotype Ontology (HPO)-based phenotype similarity has been widely used to aid disease diagnosis. However, the existing measurements are revised based on the Gene Ontology-based term similarity models, which are not optimized for...
Relative terms often appear together in the literature. Methods have been presented for weighting relativity of pairwise terms by their co-occurring literature and inferring new relationship. Terms in the literature are also in the directed acyclic graph of ontologies, such as Gene Ontology and Disease Ontology. Therefore, semantic association between terms may help for establishing relativities between...
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