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The potential of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) and its related hydroxylated analogs (2′-HO-BDE28, 6-HO-BDE47, 4′-HO-BDE17, and 4′-HO-BDE49) to modulate estrogen/thyroid/androgen receptor-(ER, TR, AR), mediated responses were investigated by use of reporter gene assays. Exposure to 1 or 10μM, 4′-HO-BDE17 significantly up-regulated expression of Luc, whereas other four chemicals did not...
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