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Non‐invasive methods have largely replaced biopsy to identify advanced fibrosis in hepatitis C virus (HCV). Guidelines vary regarding testing strategy to balance accuracy, costs and loss to follow‐up. Although individual test characteristics are well‐described, data comparing the accuracy of using two tests together are limited. We calculated combined test characteristics to determine the utility...
Chronic hepatitis B is a dynamic disease with a very variable outcome ranging from mild, asymptomatic, nonprogressive disease to end-stage liver disease and/or hepatocellular carcinoma. Clinically significant endpoints take years or decades to develop and thus various biomarkers—ranging from clinical data to sophisticated virologic diagnostics—are used as surrogates for disease progression. Liver...
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