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The interaction of integrin αvβ3 and its ligands are crucial for tumor metastasis. Recombinant CBD–HepII polypeptide of fibronectin, designated as CH50, suppressed the binding of tumor cells to ECM molecules, and abolished the promoting effect of soluble fibronectin and fibrinogen on tumor cell adhesion to ECM molecules. The underlying mechanisms involve the blockade and downregulation of αvβ3 and...
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