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Theophylline permeation experiments in poly(dimethylsiloxane) (PDMS) films modified by various amounts of a hydrophilic additive, polyethylene glycol (PEG) of molecular weight 3000 (present in the form of dispersed swellable spherical particles), were performed at 37°C. The permeability coefficients derived from these data, increase systematically from a value of P=2.0×10–10cm2/s for pure PDMS to...
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