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To investigate associations between folate-metabolizing gene variations, folate status, and unexplained female infertility.An association study.Hospital-based IVF unit and university-affiliated reproductive research laboratories.Seventy-one female patients with unexplained infertility.Blood samples for polymorphism genotyping and homocysteine, vitamin B12, and folate measurements.Allele and genotype...
This review summarizes current knowledge of the effect of folate‐mediated one‐carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate...
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