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The imbalance in expression of the human aldo–keto reductases AKR1C1–AKR1C3 is related to different hormone dependent and independent cancers and some other diseases. The AKR1C1–3 enzymes thus represent emerging targets for the development of new drugs. Currently, various enzymatic assays are used in the search for AKR1C inhibitors, and consequently the results of different research groups are not...
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