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Protease-activated receptor 1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, has been correlated with cell proliferation. PAR1 is activated by the irreversibly proteolytic cleavage, internalized via clathrin-coated pits, and then sorted to lysosomes for degradation. Caveolae play important roles in both signaling transduction and internalization of several GPCRs. However, the role of caveolae...
Protease-activated receptor 1 (PAR1), a G protein-coupled receptor for thrombin, is irreversibly proteolytically activated. β-Arrestin1 and β-arrestin2 have been reported to have different effects on signal desensitization and transduction of PAR1. In this study, we investigated whether β-arrestin1 and β-arrestin2 regulate Src-dependent activation of extracellular signal-regulated kinases 1 and 2...
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