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Treponema denticola is a proteolytic anaerobic spirochete and key contributor to periodontal disease of microbial etiology. As periodontal disease develops and progresses, T. denticola thrives in the hostile environment of the subgingival crevice by exploiting the negative regulatory activity of the complement protein, factor H (FH). FH bound to the cell surface receptor, FhbB (FH binding protein...
Treponema denticola is a primary etiological agent of periodontal disease. T. denticola evades complement‐mediated killing by binding to the host's factor H (FH), a negative regulator of the alternative complement pathway. The T. denticola FH‐binding protein has been identified and designated as factor H‐binding protein B (FhbB). Crystals of recombinant FhbB were obtained by the hanging‐drop vapor‐diffusion...
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