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Interleukin (IL)-8 and transforming growth factor (TGF)-β1 are proangiogenic factors overexpressed in advanced human melanoma. We investigated the effects of TGF-β1 on IL-8 expression in the well-characterized A375 human melanoma system. We demonstrated by enzyme-linked immunoassay and Northern blot analysis that TGF-β1 selectively induced IL-8 expression, at both protein and mRNA levels, in highly...
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