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New methodologies in cross-coupling reaction using C–H bonds as substrates is of great interest due to the challenges associated with C–H bond activation and the potential to streamline synthesis by the elimination of pre-activation of coupling reagents. In this chapter, recent developments in oxidative cross-coupling reactions will be presented with the focus on the functionalization of sp3 C–H bonds...
Copper-catalyzed trifluoromethylation via oxidative sp 3 C–H activation at the α-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert–Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15–90% yields under mild conditions.
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