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Visualization of biological targets such as crucial cells and biomolecules in living subjects is critical for the studies of important biological processes. Though 1H magnetic resonance imaging (MRI) has demonstrated its power in offering detailed anatomical and pathological information, its capacity for in vivo tracking of biological targets is limited by the high biological background of 1H. 19F...
Objective: To prepare the Gd‐DTPA‐loaded poly (lactic‐co‐glycolic acid) (PLGA) microbubbles for both ultrasound imaging and MRI imaging. Methods: Biodegradable high‐molecular‐weight poly (lactic‐co‐glycolic acid) (PLGA) was used as an encapsulating vehicle to fabricate a contrast agent composed of gadolinium diethylenetriamine pentaacetic acid (Gd‐DTPA) and fluorocarbon‐filled microbubbles by using...
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