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In article number 2000285, Katharina Landfester, Krasimir Vasilev, and co‐workers describe the role of nanoparticle shape in protein corona formation from human serum and plasma. Precisely engineered mesoporous silica nanoparticles with identical surface chemistry, but different shapes result in different protein corona compositions. Rod‐shaped particles adsorb more immunoglobulin and less albumin...
Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and treatment delivery as well as imaging and diagnostics. These advances require a complete understanding of nanoparticles' fate once placed in the body. Upon exposure to blood, proteins adsorb onto the nanoparticles surface and form a protein corona, which determines the particles' biological...
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