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The rational design of nano-carriers is critical for modern enzyme immobilization for advanced biocatalysis. Herein, we report the synthesis of octadecylalkyl-modified mesoporous-silica nanoparticles (C18-MSNs) with a high C18 content (~19 wt.%) and tunable pore sizes (1.6–13 nm). It is demonstrated that the increased hydrophobic content and a tailored pore size (slightly larger than the size of lipase)...
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