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Oncogenic Ras mutations occur in more than 30 % of human cancers. K‐Ras4B is the most frequently mutated isoform of Ras proteins. Development of effective K‐Ras4B inhibitors has been challenging, hence new approaches to inhibit this oncogenic protein are urgently required. The polybasic domain of K‐Ras4B with its stretch of lysine residues is essential for its plasma membrane targeting and localization...
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