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Recent years have seen enormous advances in nanovaccines for both prophylactic and therapeutic applications, but most of these technologies employ chemical or hybrid semi‐biosynthetic production methods. Thus, production of nanovaccines has to date failed to exploit biology‐only processes like complex sequential post‐translational biochemical modifications and scalability, limiting the realization...
In article number 2002940, Li Zhu, Wei Wei, Guanghui Ma, Hengliang Wang, and co‐workers present a Nano‐B5 vaccine platform that is fully bio‐synthesized in bacteria. This self‐assembled platform serves as a versatile chassis to combine adjuvant modular and display peptide or polysaccharide antigens. Upon excellent lymph‐node targeting and immunoresponse elicitation in vivo, strong prophylactic effects...
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