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Epigenetic‐alterations‐mediated antigenicity reducing in leukemic blasts (LBs) is one of the critical mechanisms of immune escape and resistance to T‐cell‐based immunotherapy. Herein, a bimetallic metal–organic framework (MOF)‐based biomimetic nanoplatform (termed as AFMMB) that consists of a DNA hypomethylating agent, a leukemia stem cell (LSC) membrane, and pro‐autophagic peptide is fabricated....