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Prediction of tumor motion is one of the important steps in active tracking of tumor and dynamic delivery of radiation dose to tumor. In this paper, we have presented a novel adaptive acceleration-enhanced normalized least mean squares (AE-nLMS) prediction filter based on the adaptive normalized least mean squares (nLMS) filter with predicted acceleration and ratio between the real and predicted acceleration...
Respiratory and cardiac motions induce displacement and deformation of the tumor-volume in various internal organs. To accommodate this undesired movement and other errors, physicians incorporate a large margin around the tumor to delineate Planning Target Volume (PTV), so that the Clinical Target Volume (CTV) receives the prescribed radiation dose under any scenario. Consequently, a large volume...
In our novel technique of tumor vessels treatment, High Z (HZ) contrast atoms are injected into the blood vessel and the tumor region is irradiated with ldquonarrowbandrdquo fluorescence photon (FP) beam tuned to the ldquoresonance energiesrdquo. Theoretically, this technique guarantees a dose 102 - 103 higher than that achieved in conventional radiation therapy (RT). Meanwhile, this high dose is...
Molecular oxygen is the best known mediator of radiation damage during radiation therapy. This paper investigates techniques for enhancing tumor oxygenation by use of anti-angiogenic therapy for better radiosensitivity. A noninvasive monitoring technique, Acoustic radiation force (ARF)-induced optical spectroscopy, was proposed in this paper to track tumor oxygen changes during anti-angiogenic therapy...
Radiation therapy (radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to erradicate malignant cells. Normal tissue tolerance is currently a major dose-limiting factor. As molecular oxygen plays a critical role in creating the radiation damage, we propose a novel approach, that is, the use of acoustic radiation force (ARF) to suppress the normal tissue oxygenation, for...
Tumors in thorax region incur significant amount of motion and deformation due to respiratory and cardiac cycles. To accommodate this undesired movement, physicians incorporate a large standard margin around the tumor to delineate a planning target volume (PTV), so that the clinical target volume (CTV) receives the prescribed dose under any scenario. Consequently, a large volume of healthy tissue...
As a technique for compensating for tumor motion induced by respiratory and cardiac motions, various dynamic approaches are being investigated and implemented in radiation therapy. This paper presents a novel system that can continuously track the tumor during radiation dose delivery so that a precise dose is given to a moving target while reducing dose to nearby critical organs for improved patient...
Robotic assistance can help clinicians to improve the flexibility of needle insertion and accuracy of seed deposition. However, the robotic platform is a safety critical system for its automated operational mode. Thus, it is important to perform Hazard Identification & Safety Insurance Control (HISIC) for securing the safety of a medical robotic system. In this paper, we have performed HISIC for...
In contemporary prostate brachytherapy, precise placement of needle and accurate deliver of radioactive seed at planned location is challenging. In this paper, we present a multi-channel robotic system designed for permanent seed implant in prostate. Unlike a single-channel robotic system or conventional manual technique, the designed multi-channel robotic system is capable of inserting a large number...
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