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Although the critical role of complement component C3d as a molecular adjuvant in preventing virus infection is well established, its role in cancer therapies is unclear. In this study, we have engineered a DNA vaccine that expresses extracellular region of murine VEGFR-2 (FLK1 265–2493 ) and 3 copies of C3d (C3d3), a component of complement as a molecular adjuvant, designed to increase antitumor...
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