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The zinc finger domain of the Wilms tumor suppressor protein (WT1) contains four canonical Cys 2 His 2 zinc fingers. WT1 binds preferentially to DNA sequences that are closely related to the EGR-1 consensus site. We report the structure determination by both X-ray crystallography and NMR spectroscopy of the WT1 zinc finger domain in complex with DNA. The X-ray structure was determined...
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